Research Projects:
Projects in the Kaeberlein lab have a common theme centered on identifying the genetic and environmental factors that modulate longevity and understanding how these factors act at a molecular level. We use three different model organisms for our research and work in collaboration with several other labs to accomplish our goals. Descriptions of the current projects in the lab can be found below.
Yeast Projects
The budding yeast Saccharomyces cerevisiae is the premier single-celled aging model. Our yeast projects include:
Worm Projects
The nematode Caenorhabditis elegans is the best studied invertebrate aging model. Our C. elegans projects include:
- Mechanisms of life span extension from dietary restriction
- Therapeutic targets for Alzheimer's and Huntington's disease
- Relationship between resistance to proteotoxic stress and longevity
- Hypoxic response genes in longevity and resistance to proteotoxicity
- Role of ATF-5 in C. elegans stress response
- Role of ubiquitin E3 ligases in protein homeostasis and aging
Mouse Projects
The Kaeberlein lab works in collabroation with the Consortium for the Determination of Public Pathways Regulating Longevity to test whether mouse orthologs of yeast/worm aging genes regulate life span similarly in mammals.
- Mouse longevity and age-associated disease