January 10 - Introduction
January 17 - Genetic control of obesity
- Frayling, T.M., et al., A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 2007. 316(5826): p. 889-94.
- Gerken, T., et al., The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science, 2007. 318(5855): p. 1469-72.
- Sanchez-Pulido, L. and M.A. Andrade-Navarro, The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem, 2007. 8(1): p. 23.
January 25 - Experimental methods of dietary restriction
- Greer, E.L., et al., An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol, 2007. 17(19): p. 1646-56.
- Bass, T.M., et al., Optimization of dietary restriction protocols in Drosophila. J Gerontol A Biol Sci Med Sci, 2007. 62(10): p. 1071-81.
- Harper, J.M., C.W. Leathers, and S.N. Austad, Does caloric restriction extend life in wild mice? Aging Cell, 2006. 5(6): p. 441-9.
February 1 - Insulin-like signaling in aging and dietary restriction
- Panowski, S.H., et al., PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature, 2007. 447(7144): p. 550-5.
- Bonkowski, M.S., et al., Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7901-5.
- Taguchi, A., L.M. Wartschow, and M.F. White, Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science, 2007. 317(5836): p. 369-72.
February 8 - Genetics of dietary restriction: Sirtuins
- Kaeberlein, M. and R.W. Powers, 3rd, Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing Res Rev, 2007. 6(2): p. 128-40.
- Chen, D., et al., Increase in activity during calorie restriction requires Sirt1. Science, 2005. 310(5754): p. 1641.
- Bordone, L., et al., SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell, 2007. 6(6): p. 759-67.
February 15 - Genetics of dietary restriction: TOR signaling
- Smith, E.D., et al., Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Research, In press.
- Hansen, M., et al., A role for autophagy genes in the extension of lifespan by dietary restriction in C. elegans. PLoS Genetics, Early online publication.
- Cunningham, J.T., et al., mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature, 2007. 450(7170): p. 736-40.
February 22 - Is dietary restriction only about calories?
- Libert, S., et al., Regulation of Drosophila life span by olfaction and food-derived odors. Science, 2007. 315(5815): p. 1133-7.
- Lans, H. and G. Jansen, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol, 2007. 303(2): p. 474-82.
- Miller, R.A., et al., Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell, 2005. 4(3): p. 119-25.
February 29 - Dietary restriction mimetics
- Petrascheck, M., X. Ye, and L.B. Buck, An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature, 2007. 450(7169): p. 553-6.
- Baur, J.A., et al., Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006. 444(7117): p. 337-42.
- Miller, R.A., et al., An Aging Interventions Testing Program: study design and interim report. Aging Cell, 2007. 6(4): p. 565-75.
March 7 - Dietary restriction in humans
- Holloszy, J.O. and L. Fontana, Caloric restriction in humans. Exp Gerontol, 2007. 42(8): p. 709-12.
- Heilbronn, L.K., et al., Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA, 2006. 295(13): p. 1539-48.
- Civitarese, A.E., et al., Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med, 2007. 4(3): p. e76.
March 14 - Film: “Supersize Me”